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- Boreas (Aquilon to the Romans): the Greek god of the cold north wind, described by Pausanias as a winged man, sometimes with serpents instead of feet.
- Cecrops I: the mythical first King of Athens was half man, half snake
- Dragon Kings: creatures from Chinese mythology sometimes depicted as reptilian humanoids
- Some djinn in Islamic mythology are described as alternating between human and serpentine forms.
- Echidna, the wife of Typhon in Greek mythology, was half woman, half snake.
- Fu Xi: serpentine founding figure from Chinese mythology
- Glycon: a snake god who had the head of a man.
- The Gorgons: Sisters in Greek mythology who had serpents for hair.
- The Lamia: a child-devouring female demon from Greek mythology depicted as half woman, half serpent.
- Nāga (Devanagari: नाग): reptilian beings (king cobras) from Hindu mythology said to live underground and interact with human beings on the surface.
- Nüwa: serpentine founding figure from Chinese mythology
- Shenlong: a Chinese dragon thunder god, depicted with a human head and a dragon's body
- Serpent: an entity from the Genesis creation narrative occasionally depicted with legs, and sometimes identified with Satan, though its representations have been both male and female.
- Sobek: Ancient Egyptian crocodile-headed god
- Suppon No Yurei: A turtle-headed human ghost from Japanese mythology and folklore
- Tlaloc: Aztec god depicted as a man with snake fangs
- Typhon, the "father of all monsters" in Greek mythology, had a hundred snake-heads in Hesiod, or else was a man from the waist up, and a mass of seething vipers from the waist down.
- Wadjet pre-dynastic snake goddess of Lower Egypt - sometimes depicted as half snake, half woman
- Zahhak, a figure from Zoroastrian mythology who, in Ferdowsi's epic Shahnameh, grows a serpent on either shoulder
- Enchanted Moura from Portuguese and Galician folklore appears as a snake with long blonde hair.
- Kappa: Turtle-like humanoids from Japanese mythology and folklore.
- The Lizard Man of Scape Ore Swamp in South Carolina, United States
- The Loveland Frog (or Loveland Lizard), in Loveland, Ohio, United States
- The Thetis Lake monster in Canada
- The White Snake: a figure from Chinese folklore
- Cuca, an alligator humanoid witch from Brazilian folklore.
- Reptilians appear in some claims of alien encounters and in the conspiracy theories of David Icke
- The dinosauroid, a hypothetical reptilian humanoid conjectured by palaeontologist Dale Russell.
- Other speculated sapient dinosaurs
A wide range of fictional works depict reptilian humanoids.
- Dracs from the Enemy Mine series by Barry B. Longyear.
- Evra Von from Darren Shan's "Saga of Darren Shan"
- The Horibs from the Pellucidar books
- Hork-Bajir from K. A. Applegate's Animorphs
- The Lady of the Green Kirtle from CS Lewis's The Silver Chair
- An unnamed race from H.P. Lovecraft's The Nameless City - later Cthulhu Mythos tales have named these the Valusians or simply "serpent people".
- The Race from Harry Turtledove's Worldwar series
- Serpent Men from the works of Robert E. Howard (also in the Marvel universe)
- Yig, the serpent god from H.P. Lovecraft's Cthulhu Mythos.
- Yilané from the novel West of Eden by Harry Harrison
- The Creeps and the Snake Lady from the Goosebumps franchise.
- The Troglodytes from The Trials of Apollo
- Cobra-La, and Cobra Commander from the G.I. Joe series
- Chase Young from Xiaolin Showdown
- Drakh and Narn from Babylon 5
- Lizard Man from He-Man and the Masters of the Universe
- Lizardman Phantom from Kamen Rider Wizard
- The Lizardmen from Sir Arthur Conan Doyle's The Lost World
- Scarrans from Farscape
- Sleestaks from Land of the Lost
- Slithe and his fellow Lizards from ThunderCats
- The Snake Men from Masters of the Universe
- Snake People from the TV-movie The Archer: Fugitive from the Empire
- Unas from Stargate
- Visitors from V
- The Culebra from From Dusk till Dawn: The Series
- Zafiro from Disney's Gargoyles, red-skinned snake-bodied gargate, with two humanoid arms and feathered wings, reminiscent of Kukulcan in Mayan myth and leader of his gargoyle clan
- Badoon, another hostile alien race
- Chitauri, alien shapeshifters from the Ultimate Marvel universe.
- Lizard, an enemy of Spider-Man
- The Lizard Men of Subterranea
- The Lizard Men of the Savage Land
- The Lizard Men of Tok from the Microverse
- Sauron, a Pteranodon-like enemy of the X-Men
- Skrulls, an alien race of reptilian shapeshifters
- Slither, a snake-like mutant and ally of Magneto who has been a member of the Resistants and the Serpent Society
- Stegron, a Stegosaurus-like enemy of Spider-Man
- Zn'rx (Snarks), reptilian aliens bipeds encountered by the Power Pack
- Copperhead, some versions
- Gordanians, a species of alien reptilian slavers
- Killer Croc, an enemy of Batman
- Lizardmen from the Warlord series.
- Dinosaurs for Hire, dinosaur-like alien mercenaries
- Henry Phage from the Mr. Hero comics from Tekno Comix
- Kleggs, alien mercenaries in the Judge Dredd universe.
- The Teenage Mutant Ninja Turtles, Slash, and Leatherhead
- Treens from Dan Dare
- Tyranny Rex, reptilian artist in stories published in 2000AD.
- Zarbon from anime and manga Dragon Ball Z.
- Dracs from Enemy Mine
- Thulsa Doom from Conan the Barbarian
- Trandoshans from Star Wars
- Lectroids from Buckaroo Banzai
Roleplaying and strategy games
- Argonians, a race in The Elder Scrolls series
- Bangaa, a race in the game series of Final Fantasy
- Drell, a race in the Mass Effect series
- Iksar, a race from the EverQuest franchise.
- Lizalfos from the Legend of Zelda series.
- Lizardmen from the Warhammer fantasy tabletop games.
- Naga from the Warcraft series.
- Reptites from Chrono Trigger
- Saurians from Risen
- Dinaurians from Fossil Fighters and Fossil Fighters: Champions
Platform and fighting games
- Bowser and the Koopas from Super Mario Bros.
- Espio the Chameleon and Vector the Crocodile from Sonic the Hedgehog
- Lizardman, a character from the Soul series of fighting games
- Locust Horde, the primary antagonists in the game franchise Gears of War
- King K. Rool and most Kremlings from Donkey Kong
- Reptile, Chameleon, and Khameleon from the game Mortal Kombat
- Riptor, a character from the fighting game Killer Instinct
- Pausanias (2012). Pausanias's Description of Greece. Cambridge University Press. pp. 616–. ISBN 978-1-108-04725-8.
- Elgood, Heather (2000). Hinduism and the Religious Arts. London: Cassell. p. 234. ISBN 0-304-70739-2.
- Olson, Dennis T. (1996). Numbers. Louisville: Westminster John Knox Press. pp. 135–8. ISBN 978-0-8042-3104-6.
- Hesiod, Theogony 823–835.
- Idema, Wilt L. (2009). The White Snake and Her Son: A Translation of the Precious Scroll of Thunder Peak with Related Texts. Hackett Publishing. ISBN 9781603843751.
- Lewis, Tyson; Richard Kahn (Winter 2005). "The Reptoid Hypothesis: Utopian and Dystopian Representational Motifs in David Icke's Alien Conspiracy Theory". Utopian Studies. 16 (1): 45–75.
- Frel, Jan (1 September 2010). "Inside the Great Reptilian Conspiracy: From Queen Elizabeth to Barack Obama – They Live!". Alternet. Retrieved 2010-09-01.
- Russell, D. A.; Séguin, R. (1982). "Reconstruction of the small Cretaceous theropod Stenonychosaurus inequalis and a hypothetical dinosauroid". Syllogeus. 37: 1–43.